| dc.description.abstract | Diazinon belongs to the group of organophosphate insecticides that are widely used in veterinary medicine, as topical ectoparasiticide for various animal species. Dogs generally tolerate locally applied diazinon-based preparations, however, poisoning and death may occur after the oral exposure to a large amount of this compound. Clinical signs of poisoning appear within a few minutes to a few hours and include increased salivation, difficulty breathing, frequent urination and diarrhea. In addition, neurological signs such as muscle tremor, paralysis and convulsions may occur. This paper describes pathomorphological lesions in a dog that died after oral exposure to diazinon.
A 5-year-old American Stafford Terrier died two days after the onset of the first clinical symptoms of poisoning. Symptoms included increased salivation, vomiting of hemorrhagic contents, bloody diarrhea, and later convulsions. The postmortem examination was performed at the Scientific Veterinary Institute "Novi Sad", and during the necropsy, liver tissue was sampled for toxicological analyzes. The presence of diazinon compound was determined in the liver tissue using the gas-mass spectrometry method.
The most prominent pathomorphological lesions were detected on the organs of the gastrointestinal system. The predominant changes were detected in the pancreas in the form of diffuse haemorrhages; the pancreas was markedly enlarged and edematous (about 30 cm in diameter). Ecchymotic hemorrhages were detected in serosa of small intestine, while the mucosa was hyperemic and thickened, with numerous hemorrhagic-necrotic fields. The gastric mucosa was extremely wrinkled and hyperemic, permeated with ecchymotic hemorrhages, while in the fundus part, mucous and blood clots was noticed. Haemorrhages were also detected in the esophageal mucosa. The parenchymal organs were congested, while the liver was swollen. Pathohistological examination of pancreatic tissue revealed diffuse, massive hemorrhages.
In the case of diazinon poisoning, the pathological findings are nonspecific, however, it is known that certain organophosphate insecticides (including diazinon) may lead to acute pancreatitis in humans and dogs. Although the amount of diazinon detected in this case was residual, it can be assumed that the death occurred as a consequence of a complication due to acute pancreatitis. | en_US |
