Antivirusno delovanje semene plazme sisara

Abstract

The first documented roles of the mammalian seminal plasma, apart from the direct influence on spermatozoa mobility and their functions, were connected with its action on bacteria. As early as in 1957. It was documented that bull’s seminal plasma contains substances capable for inhibiting RNA and consequently protein synthesis in E. coli. Protein that posses this activity was isolated much latter, in 1979. This effect was later confirmed also on other bacteria and viruses. It is clear that above mentioned phenomenon is significant considering the fact that natural mating is the most direct contact between two individuals that may contribute spreading of the sexually transmissible diseases. For that reason such properties of this, very complex body fluid with numerous functions, has high biological relevance. Spreading of sexually transmissible diseases is now controlled by introducing and wide implementation of artificial insemination when antibiotics are added to semen extenders and only sero-negative males are used. Despite of that, antibacterial and especially antiviral seminal plasma properties must be taken into consideration due to possible mistakes in the AI and embryo transfer technology and because of the natural mating in some mammalian species. This paper summarizes a short history of investigations in this field as well as newest scientific facts in it.