Antiviral activity in vitro of five selected indigenous plants against bovine herpes virus-1 (BHV-1) and bovine viral diarrhoea virus (BVDV)
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Date
2019-07Author
Kurćubić, Vladimir
Mašković, Pavle
Petrović, Tamaš
Lazić, Sava
Đukić, Dragutin
Ilić, Zoran
Đoković, Radojica
Petrović, Miloš
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Show full item recordAbstract
In this study, we investigated the in vitro antiviral activity of five
selected plant extracts against Bovine Herpes Virus-1 (BHV-1) subtype 1.1
and Bovine Viral Diarrhoea Virus (BVDV) genotype 1, which with other
viral and bacterial agents cause Bovine Respiratory Disease Complex
(BRDC). Ethanol (alcohol) and aqueous extracts were prepared for all five
plant species studied. Two prepared samples of aqueous plant
extracts/macerates had antiviral effect against BHV-1 as a representative of
herpesvirus (DNA virus), but none of the samples showed an antiviral effect
against BVDV genotype 1, a NADL strain, that belongs to RNA viruses. In
our study, Selectivity Index (SI = CTC50/EC50) for aqueous extracts of
Matricaria chamomilla (SI = 32) and Achillea millefolium (SI = ≥ 8)
indicates a significant selective inhibition of DNA virus (BHV-1, strain
TN41). On the basis of the obtained results, future research is needed, which
would reveal the active ingredients of the investigated plants and
mechanisms of their antiviral effect.